What causes spindle cell lesion?
What causes spindle cell lesion?
There is no definite known cause for this type of tumour, but it can sometimes occur as a result of previous radiotherapy treatment. Spindle cell sarcoma can affect any age group, but is most common in people over the age of 40.
What do spindle cells indicate?
10.69. Spindle cell carcinoma represents a rare variant of squamous cell carcinoma, characterized by spindled tumor cells that simulate a sarcoma but are epithelial in nature. The tumor can arise anywhere within the upper aerodigestive tract, with a predilection for the larynx and oral cavity.
Are spindle cells always cancerous?
Tumours made up of spindle cells These tumours can be either benign (non-cancerous) or malignant (cancerous). The type of tumour depends on the location in the body and the way the cells look when examined under the microscope. Most cancers made up of spindle cells are called sarcomas.
What is the survival rate of spindle cell melanoma?
The five-year overall survival (OS) for DM ranges between 67-89%. Advancing age, male gender and head and neck location are associated with an increased risk of DM-specific death. Controversy persists regarding the prognosis of DM compared with non-desmoplastic melanomas.
How aggressive is spindle cell carcinoma?
Spindle cell carcinoma (SpCC) is an uncommon aggressive biphasic malignancy that has the propensity to manifest itself in the upper aerodigestive tract, including the oral mucosa.
What are the symptoms of spindle cell sarcoma?
The most commonly reported symptoms of spindle cell sarcoma patients are:
- Bone pain – this may be continuous or may come and go.
- A pathological fracture may occur*– this is a fracture that has occurred due to the weakening of a bone from a disease.
- Swelling.
- The presence of a lump or mass.
- Tenderness in the area.
Is spindle cell carcinoma a melanoma?
Spindle cell melanoma (SCM) is a rare subtype of malignant melanoma composed of spindled neoplastic cells arranged in sheets and fascicles (1). The diagnosis of SCM is challenging, as SCM may occur anywhere on the body and frequently mimics amelanotic lesions, including scarring and inflammation (2–4).
Can spindle cell sarcoma be cured?
The best chance to cure a soft tissue sarcoma is to remove it with surgery, so surgery is part of the treatment for all soft tissue sarcomas whenever possible. It’s important that your surgeon and other doctors are experienced in the treatment of sarcomas.
What does spindle cell melanoma look like?
Features of spindle cell melanoma under microscopy include: An abundance of spindle-shaped tumour cells (> 90% of a tumour) Uniform, wavy, and slender nuclei, with variable size and shapes (pleomorphism) and variable nuclear atypia (abnormal appearance of cell nuclei)
Is spindle cell sarcoma painful?
The most commonly reported symptoms of spindle cell sarcoma patients are: Bone pain – this may be continuous or may come and go. A pathological fracture may occur*– this is a fracture that has occurred due to the weakening of a bone from a disease. Swelling.
What cancers have spindle cells?
Spindle cell sarcomas of the bone are often found in the arms, legs and pelvis. They most commonly arise in patients over the age of 40 and are extremely rare, making up just 2-5% of all primary bone cancer cases.
What does a spindle do in a cell?
Spindle fibers form a protein structure that divides the genetic material in a cell. The spindle is necessary to equally divide the chromosomes in a parental cell into two daughter cells during both types of nuclear division: mitosis and meiosis.
What is the prognosis of spindle cell lung cancer?
The tumor can be easily removed through surgical intervention. However, if the disease has advances in the end stage, the prognosis is poor. (2, 3, 5) The maximum survival rate is five years for people with advanced stage spindle cell sarcoma.
Do spindle cells mean cancer?
Spindle cell carcinoma is a type of cancer which usually originates in the connective tissues of the body. When cells from this type of cancer are viewed under a microscope, they appear spindle-shaped. It is a very aggressive form of cancer, and patients who are diagnosed generally do not live more than five years.
What are the symptoms of spindle cell squamous cell carcinoma?
Rough,reddish scaly patch