What causes focal glomerulosclerosis?

What causes focal glomerulosclerosis?

Focal segmental glomerulosclerosis can be caused by a variety of conditions, such as diabetes, sickle cell disease, other kidney diseases and obesity. It can also be caused by an infection and drug toxicity. A rare form of FSGS is caused by inherited abnormal genes. Sometimes there’s no identifiable cause.

What is focal segmental glomerulosclerosis symptoms?

Signs and symptoms of FSGs include: Swelling in body parts like your legs, ankles and around your eyes (called edema) Weight gain due to extra fluid building in your body. Foamy urine caused by high protein levels in the urine (called proteinuria) High fat levels in the blood (high cholesterol)

What drugs cause FSGS?

Other causes of secondary FSGS include the use of certain medications or drugs that have been shown to damage podocytes, such as interferon, bisphosphonates, anabolic steroids, heroin, anthracyclines, calcineurin inhibitors, lithium, and sirolimus.

What foods should be avoided with FSGS?

Restrictions and foods to avoid on a nephrotic syndrome diet

• processed cheeses.
• high-sodium meats (bologna, ham, bacon, sausage, hot dogs)
• frozen dinners and entrées.
• canned meats.
• pickled vegetables.
• salted potato chips, popcorn, and nuts.
• salted bread.

Can you recover from FSGS?

Fortunately, with an aggressive approach, more than 50% of nephrotic adults with FSGS may attain remission with a significantly improved prognosis. Ideally, ongoing research will improve our understanding of the pathogenesis of primary FSGS, which will allow the development of more targeted therapies.

Does hypertension cause FSGS?

Hypertension is one of the etiological factors of secondary focal segmental glomerulosclerosis (FSGS), which is mediated by adaptive structural–functional changes and associated initially with normal renal mass [4–7].

Can glomerulosclerosis be cured?

There is no cure for glomerulosclerosis. And the FDA has not approved any drugs specifically for its treatment. But several treatments can slow its progression and control symptoms.

Does FSGS cause pain?

FSGS does not usually cause pain. Tell your doctor if you feel any new pain in your back or legs. These treatments include medicines to control your blood pressure, manage your swelling, and lower your cholesterol.

What is focal segmental glomerulosclerosis?

Focal segmental glomerulosclerosis (FSGS) is a disease in which scar tissue develops on the parts of the kidneys that filter waste from the blood (glomeruli). FSGS can be caused by a variety of conditions. FSGS is a serious condition that can lead to kidney failure, for which the only treatment options are dialysis or kidney transplant.

What are the symptoms of focal glomerulosclerosis?

If the condition is advanced, the symptoms may be like those of kidney failure. People may report fatigue, a poor appetite, headache, itchy skin, shortness of breath and/or nausea. What tests are done to find out if I have focal glomerulosclerosis or FSGS?

What tests are done to find out if I have focal glomerulosclerosis?

What tests are done to find out if I have focal glomerulosclerosis or FSGS? 1 Urine test: A urine test will help find protein and blood in your urine. 2 Blood test: A blood test will help find levels of protein, cholesterol, and wastes in your blood. 3 Glomerular filtration rate (GFR): A blood test will be done to know how well your kidneys are…

What is the PMID for focal segmental glomerulosclerosis (FGS)?

PMID 10742096. ^ Brown EJ, Schlöndorff JS, Becker DJ, Tsukaguchi H, Tonna SJ, Uscinski AL, Higgs HN, Henderson JM, Pollak MR. Mutations in the formin gene INF2 cause focal segmental glomerulosclerosis.